Selected Founder Lab Papers

IL-17-Producing Innate and Pathogen-Specific Tissue Resident Memory γδ T Cells Expand in the Lungs of Bordetella pertussis-Infected Mice.
Misiak A, Wilk MM, Raverdeau M, Mills KH.
J Immunol. 2017 Jan 1;198(1):363-374.

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.
Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AA, Cooper MA, O'Neill LA, Lynch MA.
Brain Behav Immun. 2016 Dec 18.

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).
Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, Morrice N, O'Neill LA.
J Biol Chem. 2016 Nov 18;291(47):24802.

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype.
Basiorka AA, McGraw KL, Eksioglu EA, Chen X, Johnson J, Zhang L, Zhang Q, Irvine BA, Cluzeau T, Sallman DA, Padron E, Komrokji R, Sokol L, Coll RC, Robertson AA, Cooper MA, Cleveland JL, O'Neill LA, Wei S, List AF.
Blood. 2016 Dec 22;128(25):2960-2975.

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
Mills EL, Kelly B, Logan A, Costa AS, Varma M, Bryant CE, Tourlomousis P, Däbritz JH, Gottlieb E, Latorre I, Corr SC, McManus G, Ryan D, Jacobs HT, Szibor M, Xavier RJ, Braun T, Frezza C, Murphy MP, O'Neill LA.
Cell. 2016 Oct 6;167(2):457-470.e13.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.
Arbore G, West EE, Spolski R, Robertson AA, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.
Science. 2016 Jun 17;352(6292):aad1210.

Anti-PD-1 inhibits Foxp3(+) Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model.
Dyck L, Wilk MM, Raverdeau M, Misiak A, Boon L, Mills KH.
Cancer Immunol Immunother. 2016 Dec;65(12):1491-1498

NLRP3 at the interface of metabolism and inflammation.
Haneklaus M, O'Neill LA.
Immunol Rev. 2015 May;265(1):53-62.

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA.
Nat Med. 2015 Mar;21(3):248-55.

Reforming the EU environment for clinical trials: what are the challenges?
Fears R, Blum HE, Kelleher D, Meunier F, Souhami R.
QJM. 2013 Sep;106(9):787-9.

Characterising cytokine gene expression signatures in patients with severe sepsis.
Grealy R, White M, Stordeur P, Kelleher D, Doherty DG, McManus R, Ryan T.
Mediators Inflamm. 2013; 2013:164246.