Myelodysplastic Syndrome

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Fang J, Bolanos LC, Choi K, Liu X, Christie S, Akunuru S, Kumar R, Wang D, Chen X, Greis KD, Stoilov P, Filippi MD, Maciejewski JP, Garcia-Manero G, Weirauch MT, Salomonis N, Geiger H, Zheng Y, Starczynowski DT.
Nat Immunol. 2017 Feb;18(2):236-245.

Apoptosis in human myelodysplastic syndrome CD34+ cells is modulated by the upregulation of TLRs and histone H4 acetylation via a β-arrestin 1 dependent mechanism.
Zeng Q, Shu J, Hu Q, Zhou SH, Qian YM, Hu MH, Hu LY, Wang YG, Zhou YM, Lu JH.
Exp Cell Res. 2016 Jan 1;340(1):22-31.

Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms.
Herman AC, Monlish DA, Romine MP, Bhatt ST, Zippel S, Schuettpelz LG.
Blood Cancer J. 2016 Jun 17

The Role of Toll-Like Receptors in Hematopoietic Malignancies.
Monlish DA, Bhatt ST, Schuettpelz LG.
Front Immunol. 2016 Sep 28;7:390.

Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling
Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, Starczynowski DT.
J Exp Med. 2015 Oct 19;212(11):1967-85

Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases.
Cannova J, Breslin S J P, Zhang J.
Front Med. 2015 Sep;9(3):288-303.

Overexpression of miR-125a in myelodysplastic syndrome CD34+ cells modulates NF-κB activation and enhances erythroid differentiation arrest.
Gañán-Gómez I, Wei Y, Yang H, Pierce S, Bueso-Ramos C, Calin G, Boyano-Adánez Mdel C, García-Manero G.
PLoS One. 2014 Apr 1;9(4):e93404.

Overexpression of the toll-like receptor (TLR) signaling adaptor MYD88, but lack of genetic mutation, in myelodysplastic syndromes.
Dimicoli S, Wei Y, Bueso-Ramos C, Yang H, Dinardo C, Jia Y, Zheng H, Fang Z, Nguyen M, Pierce S, Chen R, Wang H, Wu C, Garcia-Manero G.
PLoS One. 2013 Aug 15;8(8):e71120.

Toll-like receptor alterations in myelodysplastic syndrome.
Wei Y, Dimicoli S, Bueso-Ramos C, Chen R, Yang H, Neuberg D, Pierce S, Jia Y, Zheng H, Wang H, Wang X, Nguyen M, Wang SA, Ebert B, Bejar R, Levine R, Abdel-Wahab O, Kleppe M, Gañán-Gómez I, Kantarjian H, Garcia-Manero G.
Leukemia. 2013 Sep;27(9):1832-40.

Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome.
Rhyasen GW, Bolanos L, Fang J, Jerez A, Wunderlich M, Rigolino C, Mathews L, Ferrer M, Southall N, Guha R, Keller J, Thomas C, Beverly LJ, Cortelezzi A, Oliva EN, Cuzzola M, Maciejewski JP, Mulloy JC, Starczynowski DT.
Cancer Cell. 2013 Jul 8;24(1):90-104.